Accelerated metabolism of voriconazole and its partial reversal by cimetidine.
نویسندگان
چکیده
We report a case of accelerated metabolism of voriconazole during therapy for invasive pulmonary aspergillosis, resulting in subtherapeutic levels. Target voriconazole levels were restored with high dosages of voriconazole (up to 40 mg/kg of body weight/day) and the addition of cimetidine as a cytochrome P450 enzyme inhibitor.
منابع مشابه
A suspected case of autoinduction of voriconazole metabolism in a patient with cerebral aspergillosis
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عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 53 4 شماره
صفحات -
تاریخ انتشار 2009